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The staggering cost of medical care and surgery combined with unacceptably long waiting times in U.S. hospitals have created a thriving new industry-medical tourism. Medical tourism or medical travel is not an entirely new concept. Until recently, medical tourists are generally a very select few who chose to travel for elective surgeries such as tummy tucks and face lifts, which combines surgery with a holiday in a place far from guaranteed privacy and a pleasant stay. In addition, there was also a limited number of people who sought medical treatment for the disease and experimental diseases such as cancer in foreign clinics. Today there are links to swelling of the integrated medical tourists by ordinary citizens looking for a wide variety of health services and medical care outside their country of origin, and that number grows each year.

For some, medical tourism and international travel Kids Health & Medical can literally be a lifesaver, allowing patients to access quality medical services that otherwise might not be able to pay. In the United States, patients without private health insurance may be faced with exorbitant medical expenses, even for the most common surgeries. Sometimes a wrenching choice to do, to have an operation to save lives and suffer extreme financial difficulties, or may not have the medical procedure and address the health consequences. For those lucky enough to have private health insurance, some may find that your insurance does not cover all medical procedures or that your insurance plan imposes unreasonable restrictions. In Canada, where public health insurance pays for most medical care, which has been well documented that the excessively long waiting times are forcing patients to take matters into their own hands and head off the coast for prompt treatment.

Medical tourism has gained media attention in recent times, and the word is spreading quickly through the excellent medical care is available at bargain prices in countries such as Thailand, Hong Kong and India. In the book, “Patients Without Borders: Worldwide Guide to Affordable, world class medical tourism, Josef Woodman author investigates this growing industry. Are reported in depth on the high quality of care in foreign hospitals and how patients who have surgery performed overseas can save up to 80 percent. For example, a heart bypass in India can be had for a fraction of the price of one in the United States.

India has become one of the world’s leading destinations for medical travelers. Over the years, India has developed a stellar reputation among medical tourists because of its state-of-the-art medical facilities that provide advanced medical procedures such as hip resurfacing, knee replacement, cardiac surgery, transplantation kidney and abdominoplasty, at prices that are a fraction of those charged with similar procedures in U.S. hospitals.

Using a medical tourism company, people who otherwise may not have been able to undergo surgery or medical treatment are able to find solutions and affordable quality health. A reputable company specializing in medical tourism medical travel arrangements to a country or a region containing some of the best hospitals in the world. In addition, make sure the hospital is staffed with some of the most highly trained surgeons and medical professionals available and to ensure the highest standards, and the most modern facilities and equipment can be obtained. Moreover, reputable companies of medical tourism will notice the success rate in these hospitals abroad.

The future of medical tourism looks bright. Factors such as improving technology and standards of care and the availability of companies that specialize in organizing medical tourism packages making international travel for medical services a very attractive proposition. Without doubt, the driving force behind the rise of travel health is the high price of medical services in North America-a factor that is unlikely to change in the near future.

“Rickets” incident in March, Jinqi Shi products in parts of the country quickly off the shelf. Reporter visited Shique has been a dramatic discovery, the “rickets door” not only led to a product off the shelf, but also caused a sort of a small “butterfly effect”, a group name of “health products” under the banner of foods for infants and young children quietly disappear from supermarket shelves.
The Jinqi Shi “butterfly effect” and a number of unrelated initiative under the brand stay away from trouble
“It is not health care products, pharmaceuticals, food, and bread.” Hangzhou consumer Ms. Yao had complaints on the “Jinqi Shi cod liver oil. Ms. Yao’s baby is 1 year old, according to her, ate the Jin Qishi product of three months after, actually, due to severe calcium deficiency cause eversion of the ribs, which is commonly known as rickets.
When interviewed by reporters, Tian Weidong, “Jinqi Shi, Managing Director admits:” Jin Qishi company’s products are food, not drugs. Only calcium, can not cure.
News which reported that media reporter visited the pharmacies and supermarkets in the Guangzhou region, accidentally discovered a strange phenomenon, a group of “children’s nutrition and health products” is not the the the Jin Qishi company’s products, but also without any contact and Jin Qishi actually take the initiative off the shelf, to withdraw the former panels placed in a prominent position on many store shelves only and Huang Jian Bao yuan two Harmony Health production of DHA and probiotics. Shelf products, without exception, are holding a “food” approval “infant nutrition”, not even the lot number of the key word “health products”.
“Food” change “health products” into the industry next rule
Management of health care products, has been a chronic problem in China in the 1990s and early 21st century, wealthy Chinese people in the food and clothing needs are met, the desire for spiritual wealth and physical health, further enhanced in this boom, many of the smash hit of the health care record sales myths, such as hearts K, three oral liquid, Peking rich in selenium Kang, three oral liquid hit a 1-year sales of 8 billion myth.
However, after unprecedented explosive sales myth, weak management and nutritional value of a scientific thesis, along with three oral liquid were dead easy to Hunan old man, “an event of burst the bubble of slowly rising a year later, the consumer confidence The rapid collapse, three collapse.
Since then, China’s unprecedented strengthening the management of health food, not only to strengthen the access system and product inspection systems more strictly regulated management approval approval of the health food made from the production qualification, product quality, approval approval, sales , publicity and other strict control to ensure that health food “is not an accident.”
One specializing in the production of advanced cancer patients taking anti-cancer “oral to industry sources, the current state of the health food approval management is very strict, not a year or so fundamental Nabuxialai, companies simply can not wait, basically are holding the approval of food production, sales, “the first listing to say” As for the approval of health food, as long as there is no much of a problem, or do down, just slow point.
As for health care products companies sell “medicine” when holding food production approval, the person in charge of joke, this is hardly the “hidden rules”, at best be regarded as rules.
Companies quick success generally fishing one vote away ”
According to regulations, a health products listed by the applicant to the State Food and Drug Administration to the provincial Food and Drug Administration (imported products) applied for registration, through information reporting, acceptance, experimental, trial-site inspection and many other steps, for 100 working days under normal circumstances, and in the event of any additional information, or disclosure of information does not meet the requirements, the approval deadline extended to 30 days.
According to the health care industry insiders, in fact, the declaration of a product, health product approval time is about 9-12 months, while the class of nutrient supplements, health products are basically a year and more, if necessary, supplementary information may be longer.
In contrast, food production approvals, is only the approval of food quality and technology supervision departments at or above the county level, State Bureau of Quality Supervision, management, the difficulty naturally greatly reduced, a lot of magic and nutritional health care products manufacturers and marketing companies are frank, the approval of health care products did not come down, but the food had already been granted, the first on the bus, buy a ticket “.
In March 2012, the State Food and Drug Health Supervision Bureau released “to further clarify the health food accessories alternative requirements”, “request” clearly states: The applicant shall, within the time prescribed by the State Food and Drug Administration, the cessation of associated products production and sales.
This is what many health care products hit the Vital health care products companies. The listing of a health-care products, in addition to the early development, post-market operations, marketing, concepts, packaging, media publicity, need a high capital investment. In addition to the minority want to build a century-old well-known enterprises, the majority of health care products companies are holding the concept of “fishing for votes left.”, A product as soon as possible listed on sales, create a sensational, quick to reap huge profits. planners proposed product ideas to put on the counter of the mall, the shorter the better, the audit as quickly as possible trouble as possible. “Quick” trend has not been fundamentally governance.
Effectiveness of health care products is hugely magnified nutritional supplements transform into a “magic pill”
At present, the efficacy of health products accepted by the Ministry of Health for approval a total of 27 classes involved in immune regulation, anti-aging, regulate blood fat, improve many aspects of bone, etc., at the same time, the definition of “health food” according to the Ministry of Health, the health food means with a specific health foods, that is applicable to specific food groups, is capable of regulating the body functions, not treatment for the purpose of food. To declare a health food product must have three attributes: food properties; functional properties, has a specific function; non-pharmaceutical properties.
In addition to more than food with a specific function can declare a health food, nutrient products included in the health food management areas, known as nutrient supplements such as vitamins, minerals as main raw material products, to complement the body of nutrients for the purpose of food , can be used to declare a health food.
However, in the marketing, sales promotion, false propaganda, exaggerating the effect, claiming that “drugs are not the role of health care treatment, and confusion between the concept of care and treatment practices, everywhere, in recent years, ginseng, Saussurea , antler, bear bile and other product prices soared, and with them the myth of health care is not unrelated. While the number covered with a high-tech cloak of “molecular products”, leaving many consumers deceived.
2015 health care products market in China 500 billion in consumer confidence into the key
Medicare Chamber of Commerce vice president of Meng Dongping said in an interview in 2015, China could become the world’s largest health care market, the market size is expected to exceed 500 billion, and how strictly regulate the management of health food to improve the quality of people’s lives, the development of this huge market, consumer confidence will be key.
The experts admitted that in the current health care market, fish, counterfeit approval, exaggerate the efficacy of such phenomena, which greatly disrupted the market and hurt the feelings of the consumers, some of the products directly harm the health of consumers. Eliminate fake and shoddy health food products, requires the joint efforts of regulatory authorities, experts, scholars and ordinary people, Huiyanshizhu, inferior products will be expelled from the health care market to protect the health of consumers.

The state food and drug supervision bureau 7, in “medical device adverse event information bulletin”, said the clinical medical staff to pay more attention to the use of infant incubator risk.

Bulletin introduction, a premature baby, female, July 16, 2010 in a hospital for preterm infant incubator thermostatic cultivation use. 21 July 2010 morning, the day nurse to give children when the temperature found its body temperature is on the high side, for 37.9 degrees Celsius, also found that higher temperature incubator. The measurement of the actual temperature incubator for 39 degrees Celsius, much higher than setting 35 degrees Celsius, the temperature by children. Clerk immediately to replace incubator children and physical cooling.

According to introducing, infant incubator is to use “convection thermal regulation” means, using computer technology to culture box temperature implementation of the servo control equipment, mainly by baby tank, temperature control meter, the incubator chassis, blue light irradiation light box etc. Its function is premature, those who were sick for infants and neonatal provide a similar matrix of uterine environment.

It is reported, from 2002 to October 2011, the state adverse drug reaction monitoring center had received about infant incubator of suspicious medical device adverse events of 332 report, mainly for temperature control, the ventilation system fault, skin rash, scratch, among which 167 cases of temperature control, ventilation system fault 50 cases, scoring four cases.

To this, the state food and drug administration to clinical medical personnel, in strict accordance with the diagnosis and treatment of standard operation, and strengthen the maintenance. Production enterprise shall guarantee the quality of products, and strengthen the operation, the users of the training.

Identification of Chinese herbal medicine is very complex object, therefore, identification of the method is varied. Identification methods are commonly used sources of identification, character identification, and physical and chemical identification of microscopic identification of such methods, in which the work associated with the largest grass-roots Drug Administration is character identification.

Character identification, is to use sight, hand touch, smell, tasting, water testing and other identification methods are very easy to identify the appearance of traits of Chinese herbal medicines, it has a simple, easy and rapid characteristics.

Traits identified generally include the following aspects.

1 shape of the herbs and medicinal parts of the shape, the shape of each medicine generally fixed. Herbs have cylindrical root, conical, spindle, etc.; skin herbs are drum-shaped, plate-like, etc.; seeds have medicinal spherical, oblate spherical. Some medicinal leaves and flowers are wrinkled, must first soaked with hot water, after the commencement of observation.

(2) size refers to the medicinal length, thickness, thickness. To arrive at more accurate size values ​​should be observed for more samples. Case the provisions of the measured values ​​vary with the size, may allow a small amount above or below the specified value. Some very small seeds herbs, should be measured under a magnifying glass.

3 colors of various herbs color is not the same, due to processing or storage of medicine improperly, it will change its natural color. Medicines to meet the requirements of color, is a measure of the quality of good or bad medicine an important factor. Many herbs not a single tone, but complex, in describing the herbs if two or more color tones should be described later, when a tone-based.

4 refers to the surface characteristics of the surface is smooth or rough herbs, with or without wrinkles, such as stomata or furry. Dicotyledonous plants, some of the top of the root class of herbs with rhizomes; monocot roots and some leaves with membranous scales; fern roots often with petiole residues and scales. These characteristics and the presence or absence, is often an important basis for identification of medicinal herbs.

5 refers to the texture of hard and soft herbs, tough, loose, dense, viscous or powder and other features. Some herbs for different processing methods, are not the same texture; starch and more herbs, such as through the cooking process, due to starch gelatinization and texture of dried solid. Identification of the experience, the term used to describe the texture of many herbs, such as light and loose, more section cracks, known as “loose bubble”; rich in starch, scattered dust when broken, known as “the powder”; soft , oil and moisture, known as “oily”; hard, translucent or shiny cross-section, known as “horny” and so on.

6 means the medicine to break when the fracture surface phenomena, such as easily broken or difficult to break, with or without dust scattering cross-section when such and broken features. Should be noted that the natural break of the cross-section is flat, or were fibrous, particulate or split sheet, wire cross-section with or without adhesive, can layers of peel and so on. For roots and tubers, stems and skin Herbs identification, observation of fracture surface is very important. If Mao herb easy to break, the cross section can be placed “from the cream” (precipitated white feather-like crystals); Atractylodes not easy to break, the section does not place “from the cream”; licorice broken when the dust (starch) scattered; Eucommia broken plastic wire connected when ; Treats fracture surface was fibrous, layered flake crack; moutan fracture surface is relatively flat, which was the powder. For the easily broken or uneven sections of medicine, to describe the morphological characteristics of cross-section, cross section can be cut with a knife, in order to view Chapi Department of the Ministry of proportion with the wood, the arrangement of vascular bundles in the shape of the distribution of radiation. For a description of characteristics of cross-section, there are a lot of experience to identify terms, such as astragalus, “Daisy Heart”; tetrandrine the “wheel pattern”; Mao herb as “cinnabar spots” and so on.

7 smell the smell of herbs directly to the nose and mouth taste and smell to identify the. Herbs containing volatile substances, most of them have a special aroma. Obvious smell of herbs, can be chopped or soak with hot water and then smell. The taste of herbs and also contains ingredients on their own, some measure of quality in the world. There is a strong irritant and toxic medicine, be especially careful when tasting, sampling less, spit it out immediately after taste, gargle, wash your hands, in order to avoid poisoning.

In addition, some herbs into the water to produce special color, with fire can produce special color, smoke, noise, etc., which, it should be observed.

Pharmacopeia is through the establishment of national technical standards to ensure human and animal drugs used in the quality, purity and concentration of drug dose and the standard of authoritative publications. It is a professional, usually under the supervision of the government’s authority to edit, and all drug manufacturing, distribution and drug treatment must comply with standards. World’s first pharmacopoeia published in Germany in 1546, called “Nuremberg Pharmacopoeia.” After a similar pharmacopoeia in different cities from time to time, but due to extensive changes between publications produced in the country led to these publications under the direction of standardization requirements.

    Pharmacopoeia standards currently used British Pharmacopoeia (BP), European Pharmacopoeia (EP), United States Pharmacopoeia (USP), the German Pharmacopoeia (DAP), Japanese Pharmacopoeia (JP), the Chinese Pharmacopoeia (CP).

    British Pharmacopoeia (BP)
    British Pharmacopoeia
    British Pharmacopoeia is the official British medical standards set, is the official publication of the British Pharmaceutical Committee, the British pharmaceutical standards is an important source. Thousands of articles of the pharmacopoeia include valuable medical monographs, of which there are hundreds of medical papers is a new theory. It not only provides readers with a standard formula, and pharmaceutical and medicine dispensing standard formula, but also to show the reader can refer to all clear-cut classification of the European Pharmacopoeia monograph. For the pharmaceutical and chemical industries, government regulators, Medical Research Institute and the students are learning a pharmaceutical indispensable tool. England The Stationery Office Press, published in the May 2001 issue of “British Pharmacopoeia 2001″ (British Pharmacopoeia 2001) is the latest version of the British Pharmacopoeia.
    Links: http://www.tradezz.com/

    Europe Pharmacopoeia (EP)
    European Pharmacopoeia
    European Pharmacopoeia Commission to coordinate the operation of the European Pharmacopoeia for the purpose, from 26 States: Austria, Belgium, Bosnia-Herceg Wei Herzegovina, Croatia, Sepulusi, Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, , Iceland, Ireland, Italy, Luxembourg, Netherlands, Norway, Portugal, Slovakia, Man Elijah, Spain, Sweden, Switzerland, Macedonia, Turkey, United Kingdom and the European Community.
Drug Quality Council of Europe Secretariat to give adaptive authentication certificate (COS), to prove that API manufacturers to produce quality products based on the European Pharmacopoeia monograph proper control. To obtain this certificate, the manufacturer needs to submit a detailed file, which may contain confidential information, the user that the certificate through the application of the relevant European Pharmacopoeia monographs, to check whether the pharmaceutical raw materials and auxiliary materials for the production of medicines for human use, that from this particular method (including raw materials) produced drugs to all possible impurities and pollution requirements of the relevant monograph complete control.

    United States Pharmacopoeia (USP)
    United States Pharmacopoeia
    USP is a non-governmental organization, is to complete the mission to promote public health by establishing national technical standards to ensure human and animal drugs used in the quality. These standards include all the people from a unique program developed, and is accepted around the world. USP is also responsible for proper use of drug released authoritative information and support to many public service programs. USP is a nonprofit organization, and through the pharmacy, medicine and other health care professional and scientific experts to provide volunteer services to achieve their goals. Currently, the U.S. Pharmacopoeia provides more than 3,700 types of prescription and non-prescription medicines, nutritional and dietary supplements and medical devices standards, which will appear in the “United States Pharmacopeia and National Formulary List” on. United States Pharmacopeia and the U.S. Food and Drug Administration, the pharmaceutical industry and other standards in the establishment of the authority of the drug has a close cooperation. These standards by the U.S. Food and Drug Administration and more than 35 other countries, government enforcement, and is recognized worldwide symbol of quality. More than 3,700 articles were standard monograph “The United States Pharmacopoeia” and the “National Formulary List” (Official Medicines rough) release. USP also offers more than 1,600 primary chemical reference standards to implement the “United States Pharmacopeia and National Formulary List” designated drug testing.
Links: http://www.eceek.com/

    China Pharmacopoeia (CP)
    Chinese Pharmacopoeia
    Chinese Pharmacopoeia compiled in the Ministry of Health, State Drug Administration under the leadership of the former State Pharmaceutical Administration, the State Administration of Traditional Chinese Medicine and other relevant departments of the Ministry of Health support, through the joint efforts of all members, relying on drug test , production, teaching, research and medical units of the force together. It is the country to ensure drug quality, safe and effective drug to protect people and the development of the code, the implementation of “Drug Administration Law of the People’s Republic”, drug quality supervision and inspection, technical regulations, but also China’s pharmaceutical production, operation, use and supervision of management must follow the statutory basis. After the founding of New China, China, has published the “Chinese Pharmacopoeia” 1953, 1963, 1977, 1985, 1990, 1995, edition 6 edition of Pharmacopoeia. June 15, 2000 the State Drug Administration in Beijing issued a “Chinese Pharmacopoeia” 2000 edition, on July 1, 2000, was enforced. 2000 edition of the book 465 million words, divided two. Pharmacopoeia, the total of 2691 kinds of western medicine varieties, increased more than 399 kinds of 1995, the number and variety of drugs have greatly improved quality.

What is film coating?

By the non-sugar coating film-forming materials obtained generally only one or two thin, as thin-film coating.

The main advantages of thin film coating:

Good quality. As the film-forming agent and auxiliary additives are most excellent physical and chemical properties of polymer materials, making the package into the film-coated tablets not only moisture, light, taste masking, wear, and easy to mildew, easy to collapse, greatly improving the drug dissolution, bioavailability and drug period, the drug can greatly expand the national and regional sales, effectively promoted the export of drugs, especially in medicine.

Less weight gain. Film-coated quality is much lighter than sugar, so heavy that the cored case, wrap weight gain after pill, which is 10 times more weight than the former, therefore, including the production of film-coated, not only in saving a lot of accessories, but also in the packaging, storage, transportation, and other aspects of taking significant savings and convenience.

Fast drying. As the fast drying, coating operation time is short, usually only 2 ~ 3h, and sugar packets usually takes 10 ~ 16h, which means, including film-coated using the same equipment as the equipment utilization rate increased by 3 times, equal to production of more than three-fold increase; and new workers to master the operation, did not sugar-coated packages must be an experienced master craftsmen to wrap. In particular, many Chinese and Western medicine have different degrees of temperature sensitive, fast drying coating time, heating time is short, but also help ensure the quality of drug core.

Image of the United States. Film-type appearance, color, logo and fresh vivid. Cored using a variety of flat curve can be shape, color can use a variety of bright colors, corporate trademark, logo can be washed directly in the drug core, the wrap is still clearly evident after the film-coated, which is to improve the corporate image that can not be underestimated .

Varieties. Now a lot of film-forming materials and accessories, carefully designed can be made into a variety of different characteristics of the film-coated, to change the core of drug release and drug release characteristics of the location, and now in addition to the stomach dissolved film, enteric-coated film, there are mouth soluble membrane (tablet), sustained-release film, release film, composite film, and the latest multi-layer, microporous membrane, osmotic pump coating, such as targeted drug delivery coating, which allows to significantly improve the efficacy .

Wide application. Now film coating has been widely used not only in medicine tablets, pills, but also for small tablets, small pills, granules, powder and other hard and soft capsules and even drugs. Film-forming materials can be used directly for film, suspensions and hydrophobic drugs dispersant.

Solvents. Coating agent in the preparation of general water as solvent coating liquid, which will not only reduce costs, but also the operating environment more comfortable, safe, but some of the water or the water will break down quickly, deterioration of the drug can only use non-aqueous solvent, in this respect there are many types to choose from.

Standardization. Film-coated tablets of design, technology, materials, quality can be standardized, then computerized, which is for the GMP management and international sales are particularly important.

Why use film coating powder coating is the trend?

Just as film-coated package is to overcome the shortcomings of sugar packets, promote its advantages and developed, as is powder coated with the coating solution to overcome the shortcomings of self, promote its advantages to develop. High-quality powder coating has the following four main specific.

Uniform quality. The coating powder of good quality in the industrialized, standardized production, from raw material, intermediate products to finished products are analyzed step by step test, meet the standards to enter the next step until the finished product. Pharmaceutical products arrive well after the sale technical service, which is the maximum to avoid the pharmaceutical companies with the coating liquid from a variety of quality problems that may occur, so as to achieve the quality of every batch of clothing like a film’s purpose.

Cost savings. The only good quality powder coating dissolved, smoothing can be immediately coated, coating preparation work I can, without reprovision hand, the provincial people, saving time, the provincial equipment, combined with clothing film quality is guaranteed. Thus, according to the calculation of total cost performance than companies with a coating liquid from a lot of cost savings.

Clean. Good quality of the coating powder itself is not easy oxidation, mildew, decomposition, deterioration, before coating is dubbed active suspension can be prepared easily occur overnight to avoid stratification, sedimentation, pollution, mildew and other phenomena.

Easy to use. The coating powder of good quality, mostly to water-soluble or alcohol-soluble, some are mixed with organic solvents or solvent, are able to now with the existing, the preparation time of only 0.5 ~ 1h, I can work the preparation of the coating, the use of very convenient.

In summary, the development of film coating must first research and development of good quality powder coating.

Thin-film coating technology problems and responses:

Bonder: mainly due to the amount of fast jet, a violation of the principle of solvent evaporation balance each other leaving the film adhesion. This occurs, should be appropriately reduced the amount of liquid spray coating, to improve air temperature, speed up pan speed.

The “orange peel” film: mainly due to improper drying, spray coating liquid low pressure spray of droplets leaving the concentration of heat caused by the uneven film wavy coat. This happens, you should immediately control the evaporation rate and improve the spray pressure.

“Bridge”: refers to the lettering on the chip caused marked membrane fuzzy clothing. The solution is: slow down the speed of spray coating, reducing the drying temperature, and should pay attention to control the air temperature.

Stain occurs: this is due to uneven mixing with the coating liquid or solid form when the character is not caused by the fineness. The solution is: with a uniform coating liquid should be stirred.

Tablet surface or edge of the coat film cracks, cracked, spalled or tablets edge wear: if the inappropriate choice of solid content coating liquid, coating machine speed is too fast, too small amount of spray caused, you should select the appropriate content of the coating liquid-solid , adjust the speed and spray volume appropriate size; if caused by poor film hardness of heart, the heart of the film should be improved formula and process.

Clothing film a “blooming”: this is due to hot air humidity is too high, spray process is too long, due to poor atomization. At this point should be appropriately reduced temperature, shorten the spray process, improve atomization.

Color difference between tablets: this is the result of fan spray jet when uneven or excessive solids liquid coating machine or coating caused by slow speed. At this point, should regulate the angle of spray gun, reducing the solid content of the coating liquid, coating machine suitable to improve the speed.

Clothing pinhole membrane surface: this is due to involvement in the preparation of the coating fluid caused by too much air. Thus should avoid getting involved with too much liquid air.

Thin-film coating technology problems and countermeasures

The early 1950s, the first real film coated tablets in the United States was born. Since then the date, film coating technology has gone through half a century of development. And our late start, late 1970s, only a small number of medical research, emerging pharmaceutical development unit and a variety of coating solution and the film coating process, and gradually expand the applications. To the mid-1990s, China was the gradual emergence of thin-film coating technology “hot.” But on the whole, the development of this technology in China is still relatively slow. Many pharmaceutical companies due to technical reasons, the application still exist many problems.

In the film the heart surface by spraying evenly sprayed on the way to a more stable polymer layer of cloth to form a few microns thick plastic film layer so as to achieve certain desired results, this process is called thin-film coating . Application of thin-film coating technology is the pharmaceutical industry needs and trends. Some people think that a good film-coated tablets did not sugar-coated tablets, no sugar-coated tablets so bright, in fact, film coating and sugar coating technology compared to traditional bag has many advantages, such as time-consuming short-coated, more moisture, light, more so on drug stability.

Pack film-coated sugar packets must change the concept, it is very important. All along, some pharmaceutical companies to film coating technology is simply seen as a separate part of the production of tablets, film-coated package as simply as sugar coated packages. In fact, not so simple. As a new technology, including film-coated tablets heart of the requirements relative to the much stricter in terms of packet sugar-coated, film hardness is high, and its mutual cooperation between the various processes, the production process of a series of technical indicators and required adjustments and mutual support are required. Therefore, the spirit must be scientific, realistic attitude towards the introduction of thin-film coating technology and application, the only way out of the chip package to achieve the desired results.

Good quality of the film coating tablets heart play a decisive impact. Sometimes poor quality piece of mechanical heart, it is impossible to film coating, even if we manage to, clothing, film quality is difficult to ensure. Heart in all matters affecting the mechanical properties of film factors, the film hardness and friability of the most important, and inferior hardness, friability becomes more prominent. In general, for the Chinese film-coated tablets package hardness should 5kg/cm3, Western film hardness should 4kg/cm3 so. How to check it? The easiest way is to hardness testing; or throw up a prime piece vertically 2 meters so that the free fall, more than twice the hardness is not qualified for the rupture. Check the friability of the simple method is to use the edge of the finger force smears or film on the surface, there is no off-chip powder were appropriate; Another method is to 30 or so tablets placed in 250ml glass in two hard rock minutes to film surface, the edge of the film who does not wear is appropriate. For hygroscopic large tablets, hardness is even higher.

Application of thin-film coating technology, coating, regardless of the high-efficiency coating machine, fluid bed coating machine, or the release of sugar for coating pan, should be in accordance with the following principles: First, the film hardness of heart to be hard enough, otherwise start coating, the film repeatedly heart and pot wall friction, there will be a loose piece, Ma surface phenomena; second film to maintain a constant bed temperature; third is equipment with spray solvent evaporation process of solvent into the To maintain balance, that is, solvent evaporation and spray rate in dynamic equilibrium.

One-sided smooth, delicate is the key to the whole process to master the pan temperature, spray volume, the relationship between speed, which is the process of film coating operations a top priority. Operation, the coating liquid for atomization of a direct impact on the appearance of the coating film of the quality of clothing, and spray atomization spray pressure and spray directly on the system. Spray the beginning, master, and blowing hot air jet speed temperature principle is: the one-sided slightly moist, but also to prevent one-sided adhesion, temperature is not too low. If the temperature is too high, too fast drying, easy film rough, uneven color film; if the temperature is too low, or spraying speed too fast will cause the pot over high humidity, and soon there will be film adhesion and other phenomena . Pan speed and the relationship between the coating operation: low speed, clothing film adhesion; high speed, clothing, film adhesion is poor, easy to peel off. Coating process, the temperature is too low, excessive spray, film flow retention, then there may be a sticky film phenomenon. At this time can increase the speed to improve, when necessary, adjust the temperature and the appropriate volume of spray, spray process, etc. to be overcome.

Powder coating quality using the same case, the problems often occur coating operation and the solution is as follows:

1, sticky film: mainly due to the amount of fast jet, a violation of the principle of solvent evaporation balance each other leaving the film adhesion. This occurs, should be appropriately reduced the amount of liquid spray coating, to improve air temperature, speed up pan speed.
2, an “orange peel” film: mainly due to improper drying, spray coating liquid low pressure spray of droplets leaving the concentration of heat caused by the uneven film wavy coat. This happens, you should immediately control the evaporation rate and improve the spray pressure.
3, the “bridge”: refers to the lettering on the chip caused marked membrane fuzzy clothing. The solution is: slow down the speed of spray coating, reducing the drying temperature, and should pay attention to control the air temperature.
4, there stain: This situation is due to uneven mixing with the coating liquid or solid form when the character is not caused by the fineness. The solution is: with a uniform coating liquid should be stirred.
5, tablet film coat surface or edge cracks, cracking, spalling or tablets edge wear: if the inappropriate choice of solid content coating liquid, coating machine speed is too fast, too small amount of spray caused, you should select the appropriate coating solution solid content, adjust the speed and spray volume appropriate size; if caused by poor film hardness of heart, the heart of the film should be improved formula and process.
6, the performance of clothing film a “blooming”: this is due to hot air humidity is too high, the spray process is too long, due to poor atomization. At this point should be appropriately reduced temperature, shorten the spray process, improve atomization.
7, the color difference between tablets: this is the result of fan spray jet when uneven or excessive solids liquid coating machine or coating caused by slow speed. You should adjust the angle of a good spray gun, reducing the solid content of the coating liquid, coating machine suitable to improve the speed.
8, clothing pinhole membrane surface: this is due to involvement in the preparation of the coating fluid caused by too much air. Thus should avoid getting involved with too much liquid air.

Coating technology in the pharmacy

Pharmacy coating is the most commonly used technologies, which involves physical chemistry, chemical engineering, fluid mechanics, polymer science and other disciplines. In recent decades, with new materials, new technologies, the continuous generation of new machinery, coating technology is developing rapidly, and forming a more complete theoretical and operational experience in the pharmacy plays an important role.

Coating is generally used in solid form preparations, according to the coating material can be divided into powder coating, pellet coating, particle coating, tablet coating, capsule coating; according to the different coating materials into sugar coating, Semi-film coating, film coating (in a wide variety of polymer materials for the foundation, including enteric coated), a special coating materials (such as stearic acid, paraffin, polysaccharides); divided according to different coating technologies spray coating, dip coating, dry-pressed coating, electrostatic coating, lamination coating, spray coating of which the most widely used, the principle is the coating liquid droplets sprayed into a mist covering the material (powder, granules, tablets) surface, and quickly dried to form coat layer; different purposes according to the coating into water-soluble coating, stomach-soluble coating, insoluble coating, sustained-release coating, enteric coating.

The role of coating include: ① damp, dark, isolated from air in order to increase drug stability; ② cover up bad odor, reduce irritation; ③ improve the appearance, ease of identification; ④ controlled drug release sites, such as spoilers in the gastric juice easily to release in the gut; ⑤ control drug diffusion, the release rate; ⑥ overcome incompatibility and so on. Coating material should have the following general requirements: ① non-toxic, non chemical inertness, heat, light, water, air stability, do not react with the coating of drug; ② can be dissolved into a suitable coating evenly dispersed in the dispersion medium in; ③ can form a continuous, solid, smooth layer of clothing, have a good crack resistance, and watertight, across the wet, shading, airtight role; ④ its solubility should meet certain requirements, and sometimes from PH to be affected sometimes only in the context of a particular PH dissolved. Also has the above characteristics of a material is also rare, it is more inclined to use the hybrid coating materials to each other.

Tablet coating the most widely used, it is often used pot pipe coating and coating-type (high-coating machine coating), which is used in film coating better. Smaller particle size materials, such as pellets and powder coating using fluidized bed coating more appropriate. Than sugar coating film coating has many advantages: ① reduce time, reduce material costs; ② no significant weight increase; ③ no bottom layer of clothing; ④ strong, resistant to crushing and cracking; ⑤ can print, die lettering does not affect ; ⑥ can effectively protect the product from light, air and moisture effects; ⑦ no adverse effect on the disintegration time; ⑧ product appearance; ⑨ for the use of non-aqueous coating provides an opportunity; ⑩ processes and materials can be standardized. Now developed a new product formulations commonly used coating film coating, film coating consists of prescribing the basic film-forming agent (coating material), solvents, plasticizers, coloring agents, can also add a porogen, insoluble fillers . Prescribing the composition of the coating film coating success is critical. The most commonly used water-soluble film coating materials include hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose (HPC), polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), enteric-coated materials, including enteric-coated acrylic resin, hydroxypropyl methyl cellulose phthalate (HPMCP), cellulose acetate phthalate (CAP), shellac, insoluble materials include ethyl cellulose (EC), corn prion.

There are so many advantages of coating the coating technology used in many medicines, the purpose of different coating materials and coating technology has to make a greater difference. Progress of the study and market demand to make coating technology and materials to form a large market, resulting in a variety of coating materials and preparation of technical professional services company, has become the coating of pharmaceutical researchers focus on the development of new formulations consider the technical means.

Improve the quality of Chinese medicine tablets – film coating technology

Thin-film coating technology, is the use of a variety of chemical stability and strong physical properties of the inert polymers and molecular differences in arrangement and structural characteristics, through the ratio of science, in the mild processing conditions, without changing its chemical properties , activation of specific groups such polymers, activated surface activity, change the original arrangement of a single material molecule to form a new film-forming mixture, that is, film-coated powder. In the film coating powder added to the solvent (typically water or different concentrations of alcohol) to form a homogeneous mixture dispersed by the spray film coating, formed on the object of a few microns thick layer of plastic film coated on the workpiece, and with good the protective effect of this process is what we call the film coating technologies. Since the 1990s, film-coated tablet production technology in medicine, Chinese medicine formulations greatly enhance China’s industrial production level and quality of Chinese medicine tablets.

Compared with the traditional Chinese medicine sugar-coated tablets, film coated tablets medicine has eight major advantages:
First, the tablets of good quality, high-grade products, greatly enhance the technology content of China’s medicine industry;
Second, a small tablet weight increase and improve the efficacy of Chinese medicine tablets;
Third, the coating speed, short production cycle, low energy consumption, high efficiency;
Fourth, the coating process is simple, labor-intensive small and easy application;
Fifth, the tablet moisture is good, convenient warehousing and transportation management;
Sixth, the sugar-free, expanded the medication tablet medicine people and markets;
Seventh, film coated tablets good stability, high intrinsic quality;
Eighth, the coating technology to achieve standardization or NC, for the requirements of modern industrial development or management.

Benefits of proprietary thin film coating technology, production operators and has been widely recognized by the consumer market, sales increased rapidly. Proprietary production process of film-coated tablets have been very mature technology in China, with the popularization and application of a variety of conditions, not too long a period of time, a great tendency to completely replace proprietary sugar-coated tablets! However, the introduction of thin-film coating technology of our time is short, and in Chinese medicine production enterprises, there are still many errors, producers lack the understanding of this technology. Here, we can discuss, share with each other, raise awareness, to jointly promote Chinese medicine tablet film coating technology forward.

First, the production cost of film coating technology

The early 1950s, the first industrial production of pharmaceutical preparations for the Western film-coated tablets technology born in the United States, after more than half a century of development, the technology in the world in the field of pharmaceutical formulations of industrial production has been widely applications. Compared with western medicine tablets, tablets medicine application of thin-film coating technology are very different, the introduction of our time is relatively late. China formally applied to thin-film coating technology medicine tablet production, is only just in the late 1990s, the time is very short. Proprietary thin film coating technology in promoting the use of industrial production in the early stages, as film-coated powder or preparation required for the production of various film-coated powder coating raw materials and machinery and equipment, imported from abroad, expensive, thin-film coating technology and high production costs, high prices of proprietary thin-film coated tablets, which hindered the process of application of this technology. In recent years, thin film coating technology, materials required for essentially localized, low cost, has been gradually approaching the production cost of sugar-coated tablets of traditional Chinese medicine, the production technology is very mature, into the application of the golden age.

From the current overall situation, film-coated tablet technology in medicine in the cost of production, if only just from the coating powder or the prices of raw materials associated with sugar-coated tablets, there is still a gap. If the overall technology to examine the whole process, film-coated tablet technology in medicine has been largely close to production costs, even with the sugar-coated tablets were flat, and there are still large decline in the cost of production space. Proprietary thin film coating technology, coupled with economic and social benefits in itself, is far more than sugar-coated tablets. This is also the recent years, thin film coating technology in the Chinese medicine industry in the application of tablet production has been rapid development of proprietary thin-film coated tablets mainly due to substantial increase in sales volume, timely introduction of thin-film coating technology, to the advanced technology for the production, should lead to the production company’s attention.

Second, the film coating is a complete set of integrated technology

And sugar-coated tablet production technologies, proprietary process to produce thin-film coated tablets, is a fully integrated technology, all aspects are indispensable. Proprietary technologies such as thin-film coating die hardness, surface finish, materials selection, process operation and so very different production techniques with sugar-coated tablets. If the borrowed sugar-coated tablet production methods or technology, film coated tablets applied to medicine, often not achieve the desired effect, and even different varieties of Chinese medicine, due to the die surface properties is not the same, can not use the same kind of film package powder coat or coating methods. Many pharmaceutical manufacturers to introduce thin film coating technology, manufacturing proprietary coated tablets, the results unsatisfactory, achieving its purpose, the crux of it due to this.

Follow the traditional method of processing or production of proprietary materials die, for the production of thin film coated tablets, tend to occur mainly the tablet disintegration time, hardness die poor, rough and a series of one-sided problem, resulting in medicines of poor quality film-coated tablets. To solve these problems, the most effective way is to start from the selection of new accessories, adjusting feed formulation, production process and related procedures be amended accordingly and so on. In particular, the choice to use the new materials is very important, rapid development in Europe and America, and thus derive a new industry – (Pharmaceuticals) fine accessories. Chinese medicine preparation industry enterprises active in the introduction of film coating technology, should also be from a higher level or point of view, but also on the level of their own production techniques to adjust and improve a scientific opportunity to do both, so as to enhance the overall management .

Third, the rational use of film-coated powder

Sugar-coated tablet production technology, suitable for almost all of Chinese medicine and Western film film. Film coated tablets technology is different, because medicine is more complex composition, film-coated powder material used or due to different formulations vary greatly, the die surface properties of the physical characteristics and differences in the selectivity of the film coating powder strong. As a thin film coating powder and technical parameters are often only suitable for one or a few pieces of proprietary Chinese medicines. Different varieties of Chinese medicine die by small tests, you can easily find the film coating powder used in the production. In general, Chinese medicine and the die surface must be film-coated powder has a good affinity, high-quality medicine in order to produce thin-film coated tablets, which is the introduction of an important part of the technology. Different physical properties of proprietary Chinese medicines of different die, the choice of matching pink film coating, film coating is a proprietary technology and production quality is good or bad success and a key factor in tablets.

Fourth, the quality of film coating powder

Relationship between the quality of film coating powder to the quality of proprietary thin-film coated tablets, an important factor. Some Chinese medicine production enterprises in the introduction of thin-film coating technology, they tend to take self-made film-coated powder method for factory use, the deployment of this homegrown way, is just a few years ago our film from abroad coating technology early, there are no professional manufacturer of powder coating film or film-coated powder imported under the conditions of the price very expensive, proprietary producers had to do the worst, leading to unstable production technology proprietary thin film coating , tablets, poor quality, production technology and other issues can not be quantified, is not conducive to the promotion of the technology.

In recent years, Indoor Light Fixtures have been the emergence of a professional manufacturer of film coating, has been able to produce various types of film coating powder, film-coated tablets for the medicine production and use; film coating can also be based on proprietary manufacturing plant tablet formulation of the specific requirements of business or specific targets, set and match the technology of special film coating varieties, provide pre-sale support services, to produce high quality proprietary thin-film coated tablets. At present, the powder coating film production industry R & D and production technology and the international advanced level of gap is narrowing fast, high quality, variety, good performance, has been fully able to replace imported products, while China’s production of thin-film coating powder also supply a large number of export. Film coating powder production in China R & D innovation and production capabilities greatly enhanced, proprietary thin film coating technology for the application, reduce production costs and improve the quality of Chinese medicine tablets injected new vitality, but also for medicine production enterprises refer to film-coated tablets of advanced production technology to create a good back-up material security conditions.

Fifth, film coating technology operating problems

In Chinese medicine tablet production, the introduction of thin-film coating technology or production process, often there will be some problems, such as pasting, orange peel film, pinhole, color tablets, spray, chipping, stains, etc. In the current production technology or equipment conditions, is very easy to solve, film coating technology is no longer a problem. Especially in recent years, China’s pharmaceutical preparation machinery industry by introducing and digesting international advanced technology, our preparation machinery driven the rapid development of the industry, to speed up the localization process. If current production of high-performance thin-film coating pan and main technical parameters are close to or even reach the international advanced level, the sales price fell sharply preached trend, only 20% of similar imported machinery. Tablet film coating technology in the production of proprietary applications, due to film coating made of inexpensive and efficient mechanical equipment, universal and more simple, proprietary thin film coating manufacturers to introduce production technology should be confident. As long as we film coating by adjusting the efficient operation of mechanical equipment specifications, process procedures scheduled, you can easily make the film-coated tablet manufacturing process proprietary quantitative or numerical control technology, easy to learn technique, the production of technical problems it is solved for a wide range of proprietary thin film coating technology application provides a guarantee of success.

Alias: ascorbic acid, vitamin c, vitamin c-type.

Pharmacology: vitamin C can reduce the blood capillary permeability, accelerate the blood clotting, stimulate hemopoietic function, and promote the iron in the intestinal absorption, reduce blood triglyceride and cholesterol, increasing the resistance to infection, participate in detoxification function with antihistamine and prevent carcinogenic substance (nitrosamines) generation role.

Preparation: tablet: 0.05 grams per piece; 0.1 grams. Injection: each 0.1 g / 2 ml; 0.5 g / 5 ml; 2.5 g / 20 ml.

Clinical new USES:

1. For a cold

Methods: oral daily vitamin C 1 g. Or will vitamin C piece of research into powder, in both sides of the nose of add some, then rest in bed. Efficacy: nostrils put medicine within 5 minutes after, nostril inside the thick nose goes lean and with nostril outflow, the second day cold symptoms disappear.

2. Treatment sclerosis of arterial congee appearance

Vitamin C can control atherosclerosis, and its function mainly is to reduce blood triglyceride and cholesterol, and to the liver, the kidney fatty infiltration has protective effect. Methods: vitamin C 0.5 ~ 1 g, 3 times a day oral; Or the same dose every day 1 static note, six months for a period of treatment.

Efficacy: according to the report, the daily static note vitamin C 1 g, three days later can make more than 50% of the patients serum cholesterol down, also visible lipoprotein decreased. But there are also not very satisfactory curative effect of the report.

Note: this method used by vitamin C larger doses, should avoid to use for a long time. Pregnant women are prohibited.

3. The treatment of chronic hepatitis

Recently with large doses of vitamin C chronic hepatitis treatment made remarkable curative effect. Vitamin C can promote liver cell regeneration and glycogen yuan synthesis, enhance the ability of a protein synthesis liver, strengthen liver ability to detoxify, promote metabolism and improve liver cell disease-resistant ability.

Methods: vitamin C 2 g, 3 times a day oral; Or intravenous 2 ~ 5 grams. Treatment 10 to 60 days.

Efficacy: according to the report, the shots vein (every day 1, 5 ~ 10 grams of static note, total 70 ~ 32 treatment l g 10 to 60 days, treatment), the 10 cases of chronic hepatitis to patients, 6 were markedly improved, 3 cases effective, 1 case is invalid.

4. Treatment hand peeling

Method: first will wash clean, stay a little after working, but people with vitamin C injection in the palm, and then ShuangZhang solution will wipe divide evenly, wait for dry white liquor backwardness when washed away. 2 times a day, every time 2 ml.

Efficacy: a report with vitamin C treatment for patients with hand peeling, light person 1 time powerfully, the person that weigh 3 times got, the more can a few days.

5. Treatment of simple stomatitis

Simple stomatitis, commonly known as the KouChuang. Generally the treatment of this disease in addition to give the vitamin, local use l % LongDanZi outside tu, usually need to 5 ~ 7 days to heal. With the switch to vitamin C, the effect is more significant.

Methods: vitamin C tablets (0.1 g) crushed into powder, powder and in ulcer surface, silent for a moment. 2 times a day, 2 ~ 4 days can be healed.

Note:

1. The product turn yellow in color after avoid.

2. This product with heparin or warfarin and, can cause prothrombin time is short.

3. Vitamin C is unfavorable and alkaline drugs, such as sodium bicarbonate, monosodium glutamate, aminophylline etc), lactoflavin, dichloroisocyanuric uncle butanol, copper, iron ion (trace) solution compatibility, lest affect curative effect.

4. Vitamin C daily dosages more than 5 grams, can lead to hemolysis, the person that weigh can endanger life. Pregnant women in large doses, can lead to baby from scurvy.

In the 1950 s, Chinese and western medical technical personnel in the proportion of 1:1. By the end of 2002, the national health agency has 85705 companies, including traditional Chinese medical treatment institutions 3801, occupy 4.4%. By 2006, the medical institutions of traditional Chinese medicine had fallen to 3009 home, accounted for only 3.5% of the total number of medical institutions, and this gap still continue to lead. Now the Chinese medicine hospital of traditional Chinese medicine treatment rates low, are common for emergency and severe cases JiuZhenLv low, Chinese herbal medicine usage low “three low phenomenon”. So, someone speaking, the western medicine moves forward, traditional Chinese medicine is go back, will one day return to the edge of the cliff of traditional Chinese medicine, and finally to withdraw from the market.

Why the contrast of traditional Chinese and western medicine so big? I think the reason is very simple, western medicine is constantly absorbing the latest achievements of modern science and technology, and after the founding of the Chinese medicine for decades, complacent and conservative, no major breakthrough and innovation. The fine tradition of traditional Chinese medicine “top know astronomy, bottom know geography, known in personnel”, have already lost, traditional Chinese medicine is the inevitable decline.

Traditional Chinese medicine can’t advance a crucial question is what is the culture of traditional Chinese medicine or science, or both. The author firmly believe that, TCM is scientific, medical science, is not a culture or culture and science. Because she is science, must accept the scientific means test, to verify TCM therapy effect. 1997 Chemical Manufacturers issued “on health reform and development of the decision and clearly put” realize the modernization of traditional Chinese medicine “goal, has now been ten years, the progress of the modernization of traditional Chinese medicine is very slow. Why can cause now walking difficult situation? First is’s always as “what is the modernization of traditional Chinese medicine” debate; Next up is “Chinese medicine now

Generations of the “very few people, so progress will not quickly; the third is the traditional Chinese medicine strategist too little, and can speacially coups, foresight, and the future too little, comes up with a high level of Suggestions, doesn’t have a high level of way, can’t find out and the Chinese medicine fate of key problems at stake, so Chinese medicine is also expected decline gradually.

How to modernization of traditional Chinese medicine? Talent is key, so will be the first to cultivate a large number of modernization of traditional Chinese medicine of talents. In the university of Chinese medicine in the collection of the modernization of traditional Chinese medicine to open this even read system. The author thinks that the right talent cultivation frame of Chinese medicine are as follows: first read Chinese medicine and modern medicine specialized foundation, study later complexity science and higher mathematics, and research methodology, evidence-based medicine in scientific research class. Complexity science (some called system science), which mainly includes a system, information, cybernetics (past says “old the three”), and the dissipative structure theory, coordination theory, theory of mutations (” new the three “), and the cycle theory, chaos theory, the fuzzy mathematics, etc.

The modernization of traditional Chinese medicine is a important content of modern advances in research on the complexity of the system and the Chinese medicine research constantly combined, give the ancient Chinese medicine phenomenon, the theory of traditional Chinese medicine, experience, formula and a modern science of complexity explanation. One example: chaos theory to study the theory of Chinese medicine has come to a quite high. Chaos learn recent research thinks, “the Chinese medicine cure has been recognized, but with the traditional biology, physiology or ideas of physics, can make to the exact and satisfactory explanation. And chaos theory, a branch of the fractal theory, from a new point of view are discussed, which makes the Chinese medicine cure principle explanation achieved satisfactory results. So, will boost the new development of traditional Chinese medicine theory.

Fractal theory in the traditional scientific confused place, often use it freely. Especially the chaos, the rules of the more complex, no field, the fractal theory can show that it is effective. Chaos is about a process of science, not on the state of science, is about the evolution of science and not about the science of existence.

Biological internal between the parts and biological and environmental between, have interdependent relationship, the dependent relationship is often nonlinear, constitute the balance of the macro orderly structure. And the balance of Yin and Yang, traditional Chinese medicine Yin flourishes while Yang declines, YangCheng Yin failure, five line viscera XiangShengXiangKe, is “chaos” theory of human body between departments are interdependent, and mutual competition, synergies of ancient description. And health and disease is the “same period oscillations” over time and space orderly change happened macro. In fact, the complexity of the system is not only the number of interaction department, more in the kinds of interactions are, the change is. The interaction system formed emergence, nonlinear, order, dynamic characteristic, random, since eligibility, self organization such complex mechanism and laws, and traditional Chinese medicine for human research, not have the various characteristics?

If press this train a number of modern Chinese medicine, complete a batch of high levels of scientific research project, the modernization of traditional Chinese medicine are assured. By that time, around the world will pay high attention to the medical home of China’s modernization of traditional Chinese medicine school of academic achievement, also can appear the argument of traditional Chinese medicine to die?

2006 years of new drug to market, the lack of blockbuster new drugs, but “boon degree” “bo road set” has brought people expected, particularly to China for the pharmaceutical industry, “well degree” the symbolic significance of more than the actual value of the industry.

NO. 1 grace degrees

Recombinant human endothelial statin antitumor kind of new drugs, by yantai wheat get tianjin for biological engineering Co., LTD dr LuoYongZhang presided over a research and development. In August, after 8 years hard exploration, this institute has a number of independent intellectual property rights of the world the first recombinant human endothelial statin of new cancer drugs into the market, this marks China’s in vascular inhibit class of r&d and production of cancer drugs are walking in front of the world. The drug from drug design to preparation technique is more significant breakthrough in the world, will be for the recombinant human endothelial statin large-scale success resilience, and developed kg class preparation technology; The first person to be restructured vascular endothelial statin develop resistance to new cancer drugs, and to verify the exact curative effect; Get the national a class certificate and new drugs.

NO. 2 Rg3 CanYi capsule

A class of traditional Chinese medicine monomer cancer new drugs, jilin establish pharmaceutical Co., LTD, development production, 2 months on the market. The research project in national torch plan projects, the national key new product, national 15 key research projects. This is our independent development, complete with independent intellectual property rights of the first Chinese medicine preparation monomer new cancer drug, its main component is ginseng saponins Rg3, it has selectively restrain cancer cell invasion and metastasis of the special role pharmacological effects. Its presence, will change the present YaoShi cancer treatment on the chemical synthesis drug predominant situation. At the same time, it has changed the traditional Chinese medicine role composition is not clear and role clearly targeted weakness, make our country of traditional Chinese medicine to international possible.

NO. 3 Po and decide

With hepatitis b virus oral drug, general name on entacavir piece, by the American bristol-myers squibb publicly developing production, 2 month announced in China market. The key is for hepatitis b treatment for hepatitis b virus replication, reduce restrain virus DNA level, this new drug for the treatment of chronic hepatitis b listed first-line use provided new choice. Two years of clinical trial data shows, bo road is the role of the strongest set with hepatitis b virus drugs, antiviral activity than other nucleoside drugs 300 times stronger than the very significantly reduce hbv-dna levels, and no resistance phenomenon; At the same time, “bo road for nucleoside drugs for patients treated first, that never used nucleoside drugs treatment of chronic hepatitis b patients, curative effect more apparent”.

NO. 4 AnKeRui dissolve tumor virus kind of drug

AnKeRui dissolve tumor virus kind of drug, belongs to the antitumor drugs, by the Shanghai medical group affiliated enterprise Shanghai 3 d pharmaceutical Co., LTD, research and development, and also has the domestic and global intellectual property rights, is also the first formal devotion market of dissolve tumor virus kind of drug. October 22,, the market, the current market price for 3690 yuan a, new drug in 2007 is expected to sales will reach 50 million yuan.

NO. 5 bond Laurie

Cancer treatment of bone metastases of the third generation of double bisphosphonates to drugs, general, called “the class phosphonate” by roche pharmaceutical Co., LTD, research and production, July in listed companies in our country. Double phosphonate salts preparations to pathological bone resorption as targets, has high affinity for bone tissue, can selectively deposition in the bone remodeling active part, is for malignant tumor bone destruction and its complications caused by the first choice of treatment. Apply to prevent neoplasms with bone lesions and treatment of patients with bone tumor induced hypercalcemia.

NO. 6 to lexapro

New type of antidepressant drugs, by xian-janssen pharmaceutical LTD, the company production, in our five city 6 hospital treatment more than 220 patients with satisfactory results, allowed to go on sale in China in early July. Dosage of the drug on the market at present than the drug dosage is reduced by half, and work fast, high security, generally in 1 ~ 2 weeks can reduce disease patients.

NO. 70000 he d

China’s first new drug therapy for pulmonary arterial hypertension, first by the German company research and development production spirit, April announced in China market. All he d chemical called in front row (ILOPROST) los meal, and its chemical structure and endogenous forefront ring grain similar. A use all he d Ⅲ level and Ⅳ treatment level of pulmonary hypertension long-term clinical studies show that: the drug for patients with pulmonary arterial hypertension effect is good, can maintain lasting clinical effect. At the same time in maintaining the clinical effects without a significant increase in the dose.

NO. 8 xi well away

This is our country the first use of Marine biological therapy cranial nerve system diseases, Chinese herbal medicine new medicine, won a national key new product certificate. Zhejiang HangKang pharmaceutical research and development production, June approved listing. The effective use of the sea creature of the active material, is combined with traditional Chinese medicine dialectical theory developed nerve system disease treatment of new drugs, it fill in the Marine creatures in the blank of medicinal field, has been listed as the state’s basic drugs directory.

NO. 9 profit lung profoundly particles

Traditional Chinese medicine cancer drugs, by the China traditional Chinese medicine academy of sciences after 20 years of the successful development of new drugs, to the small cell lung cancer survival quality and improve immune function is higher than the effect of chemotherapy. At the same time, for many years almost no antitumor innovation Chinese medicine market, through the state food and drug supervision bureau approval to “profit lung profoundly particles to” break the routine. This is our country cancer treatment of Chinese medicine field another important achievement of.

NO. 10 AnSu silk

Treat acne drug for external use, general, called “different d A acid”, by novartis research and development production, April announced in China market. The current external use d A acid drugs are the basic medicines treating acne, have fight acne formation and dissolve acne function, and the antimicrobial effect. But the earliest development of all the trans d A light and antioxidant in acid can decompose, have apparent “d A acid dermatitis” side effects.